Transplantation of Nurr1‐overexpressing neural stem cells and microglia for treating parkinsonian rats
نویسندگان
چکیده
منابع مشابه
Intrastriatal transplantation of adult human neural crest-derived stem cells improves functional outcome in parkinsonian rats.
Parkinson's disease (PD) is considered the second most frequent and one of the most severe neurodegenerative diseases, with dysfunctions of the motor system and with nonmotor symptoms such as depression and dementia. Compensation for the progressive loss of dopaminergic (DA) neurons during PD using current pharmacological treatment strategies is limited and remains challenging. Pluripotent stem...
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Purpose: Parkinson's disease is a degenerative disease produced by the death of dopaminergic neurons, and the response to current treatments is varied. It is important to develop a model for the evaluation of ES cells as an alternative model for treatment. Materials and Methods: The model for PD was developed in rats. First, ES cells were transplanted into experimental models in three groups: ...
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ژورنال
عنوان ژورنال: CNS Neuroscience & Therapeutics
سال: 2019
ISSN: 1755-5930,1755-5949
DOI: 10.1111/cns.13149